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On the nuclear side I think the danger is purely reputational damage towards the company behind the LLM.

If a journalist can prompt the LLM to tell them how to build a nuclear warhead. Even if the output text is nothing specific, or not even correct they can find an “expert” who will claim on the record that the description is plausible and at least directionally correct. Even if there is nothing in there a first year physics student wouldn’t already know. The journalist could then twist that story into a “company X’s LLM told us how to build a nuclear weapon”. It would be a PR disaster.

The real barriers to someone starting their own nuclear weapons program in their shed is not knowledge but materials. They won’t have the right kind and right quantity of fissile material. And if they try to acquire it they will stick out like a sore thumb. You can’t buy that stuff. And even just acquiring the refining capacity would be suss. It would ring all kind of alarm bells to the kind of inteligence agencies whose job is to monitor these things.

I’m a lot less certain about biological dangers. Setting up a lab where you can make dangerous biological materials require a lot less stuff. Therefore a lot more plausible that someone could hide their lab. There is also a lot more opportunity to disguise such a lab as something legitimate. Therefore lack of know-how is more of a limiting factor there.


Is it worse than reputational damage from having a power trip? Or rather being on it permanently, looking at Anthropic and Dario Amodei in particular.

It is. But doesn’t fit with the rest of the sentence.

“In a television studio, theatre or concert hall, the room where performers await their entrance.” https://en.wiktionary.org/wiki/green_room


Do you feel the same way about walking? If you wanted to get anywhere on land pre Bronze age your only option was to walk. Then we started riding horses, later we invented carriages, much much later bicycles, cars, and airplanes. Do these also take away something about being a living, breathing being? Do you feel that your life is lessened by these options?

A different question is. Imagine that you are living with a partner and you agree on a distribution of labour. Let’s say you do the hunting and your partner cleans the house. They are happy with the agreement and fully consent to it. Do you feel it takes away from you being a living, breathing being?


> Cube; that was done in 3 weeks

The cube was not “done” in 3 weeks. Maybe they shot it in 3 weeks, but there were years of pre-production, and at least months of post-production. (According to wikipedia.)

Saying that it was done in 3 weeks is like saying that windows 11 was done in 45 minutes, because that is how long the compilation lasted.

> with budget of $350,000 CAD

“50% of the budget as C$350,000 to C$375,000 in cash and the other 50% as donated services, for a total of C$700,000. Natali considered the cash figure to be deceptive, because they deferred payment on goods and services, and got the special effects at no cost.”

Direct quote from wikipedia.


Fair enough, I was looking at budget fields on wiki rather than reading the tidbits - thanks for the correction still!


> Loss of human life in a static fire is criminal.

True. And yet it is not without precedent.

Scaled Composites had an explosion while performing a cold flow test of SpaceShipTwo’s engine which killed 3. https://www.latimes.com/archives/la-xpm-2007-jul-27-me-explo...


> Why are you being mean?

They are not. They are blunt.

> why are you defending slop?

Because they don’t believe it is slop. They believe you are unable to comprehend a not too advanced literary device and based on that accusing that the text is slop.

On the topic of kindness: You might be right and it is AI generated slop. You might be wrong. If you are wrong what you are doing is deeply and utterly unkind. Not calling out the other commenter, but calling the writing slop.

It has happened with me before. I wrote a comment on reddit with my own hands and own mind and commenters accused me of being a bot. There is nothing more rage inducing. How can one respond to that? Have you thought that maybe that is what you just did? Are you 100% sure that it is slop?


It's confirmed as AI-assisted writing: https://news.ycombinator.com/item?id=48247127#48248070


The thing is that whether it's AI-assisted or not doesn't really matter. It's still clearly a metaphor.

Maybe I was being mean - I don't know if the person I replied to has English as their first language, and if not, then perhaps I'm railing against the wrong comment. If so, I guess I should apologise.

If English is their first language, though, well I would expect my 13-year-old son to be able to tell me that was a metaphor instantly, and I tend to expect better-than-teenager-level reading comprehension from people in general. It's kind of disconcerting just how many people on HN seemed to be flummoxed by the prose.


How do you know that is a “gut ecosystem collapse” as opposed to hypermotility? Or an overgrowth of the gut ecosystem? Or a problem with the intestinal lining?

Observing that if you eat/drink something specific then you get the shits is valid. Concluding that it is due to a specific mechanism is not valid unless you have something objective like a test supporting that.

It’s like if your train is late and you just conclude that it must be because the steam condenser’s gasket is leaking based on nothing. Maybe true, or maybe the conductor broke his leg, or there is a signaling failure.


Ummm…because all of those symptoms you listed are symptoms of gut dysbiosis…?

Why do you need to know what the mechanism is to avoid mistakes? - if something fucks you, don’t do it.

Encourage others to do the same.

Not a controversial take!


[Gut Flora Summit banner]

“But what if it’s a big hoax and we create solid stools for nothing?”


Seriously, though!

This demand for peer-reviewed evidence in place of observation of known and basic mechanisms is out of control.


If you drop an ACME 100Kg anvil on your foot, you get a broken foot, and you can conclude "this fucked me, I won't do it again". But if you say "I suffered foot ecosystem collapse" and people ask you what that means and how you identified it, whinging about how people should stop asking stupid questions because all bad things are bad therefore they must be the same thing, is not helping anyone.


Except, you intentionally replied up here, and not down below,

where you’d have to reply to “well-understood and basic mechanisms” being ignored.

Including the ones we know inhibit a healthy diverse microbiome!

Sticking with your chosen example:

If you lean an anvil on your foot, and start suffering from poor circulation or discoloration of the foot, remove the anvil.


> therefore they must be the same thing

Also, this bit is a non-factual read (don’t put words in my mouth, mate, I choose them carefully).

An uncharitable, bad-faith interpretation at best.


> if you take the highly reciprocal data of a biological connectome and unroll it into a DAG, you suddenly see motifs popping up that look similar to what we find in AI

That sounds interesting. Where have you heard about that? Or is this your own research?


> you'd rather say Andreessen-Horowitz, which is just as arbitrary as a16z

Yes. I know Andreessen-Horowitz and I don’t know a16z. Reading the title i thought it will be about the cryptography serialisation specification. Turns out i was mixing it up with ASN.1.

> Their website is literally a16z.com

I hear now. Before this if pressed i would have guessed that they probably have a website indeed. If you would have twisted my arm my guess would have been andersenhorovitz.com (yup, with the typos. I learned the correct spelling today from your comment.)

> exceedingly relevant for the HN audience

We contain multitudes.


> Yes. I know Andreessen-Horowitz and I don’t know a16z.

So the world needs to adapt to your knowledge instead of you learning to adapt to a often used, and well-known moniker?


They just want to sound technical.


> This study is based almost entirely on pre-existing "vignettes."

This is basically the only way how to ethically approach the topic. First you verify performance on “vignettes” as you say. Then if the performance appears satisfying you can continue towards larger tests and more raw sensor modalities. If the results are still promising (both that they statistically agree with the doctors, but also that when they disagree we find the AIs actions to fall benignly). These phases take a lot of time and carefull analysises. And only after that can we carefully design experiments where the AI works together with doctors. For example an experiment where the AI would offer suggestion for next steps to a doctor. These test need to be constructed with great care by teams who are very familiar with medical ethics, statistics and the problems of human decision making. And if the results are still positive just then can we move towards experiments where the humans are supervising the AI less and the AI is more in the driving seat.

Basically to validate this ethically will take decades. So we can’t really fault the researchers that they have only done the first tentative step along this long journey.

> if the Internet somehow goes down at my hospital, the Doctor can still think, while LLM services cannot

Privacy, resiliency and scalability are all best served with local LLMs here.

> If the power goes out at the hospital, the Doctor can still operate, while even local LLMs cannot.

Generators would be the obvious answer there. If we can make machines which outperform human doctors in realworld conditions providing generator backed UPS power for said machines will be a no brainer.

> You're going to need to improve the power efficiency of these models by at least two orders of magnitude before they're generally useful replacements of anything.

Why? Do you have numbers here or just feels?


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