Nobody is ever going to do that with this test, because the overwhelming majority of positive test results in a population-wide sample will be false, and the proposed diagnosis is devastating. This is a test for people who already have symptomatic dementia that helps confirm the diagnosis.
Well this test isn't for whether you will get Alzheimer's, so that disqualifies it before we even consider the accuracy.
But apparently your odds go above 30% if you live long enough, so if you could test for being in that cohort I think that result would be too common to actually be devastating.
> Tell 50 million people they’re likely to have Alzheimer’s then tell them where to donate towards a cure, or treatments to slow it by a decade.
Pharmaceutical companies have spent something like $50 billion on developing Alzheimer's drugs with, well, the most furtive of straw-grasping to show for it. It's probably the most expensive single disease target (especially as things like cancer are families of diseases)... the failure to have good results isn't for lack of money, and merely throwing more money at it is unlikely to actually make progress towards meaningful treatments.
It just seems really obvious to me that it's not one disease. One problem with the research is that there is SO much money. It's corrupting. There's a whole thing about the plaque cartel and if you aren't testing around a possibly flawed concept the availability of funds is much lower.
I just feel the thinking is off, it's like we are trying to treat cuts by removing scabs and scar tissue. We really need deep investigation on the sources, which I feel in many cases are industrial chemicals and how some people's body / immune system respond to them.
One of the most compelling studies I saw was how distance from a Golf Course predicted neurodegenerative diseases, based on their use of certain pesticides.
I wonder if after services like 23andMe became popular and millions of people found out they have the Alzheimer genes, did donations towards brain research rise?
Can you elaborate on that point? I didn't downvote you, but I'm also not going to watch a 3-hour #metoo video about a guy from my grandfather's era in order to understand what you mean.
What's next... is she going to tell me that Newton was a real asshole? Noooooo, say it isn't so.
It’s discussed in the first few minutes. That’s basically all I watched. One of the first points she tries to make is that people claim that Feynman is one of the top physicists of all time, comparable to Einstein and Newton. She tries to set us straight.
Anyway, I’m a big Feynman fan. My Discord handle is feynman1918.
“The reversal targets the 2009 “endangerment finding,” which concluded that six greenhouse gases pose a threat to public health and welfare. The finding provided the legal underpinning for the Environmental Protection Agency’s climate rules, which limited emissions from power plants and tightened fuel-economy standards for vehicles under the Clean Air Act.”
Installation costs dominate the price. I check every few years, and while the hardware is down to about $5k for me, cost for installation remained $45k-$50k. Which is where it’s been for years. Makes diy very attractive though.
This is bananas. Ten years ago I paid £5.5k for a whole 3.9kW installation, which has now more than paid for itself. I can see why everyone in the US is saying "get a trade job", you can rip off householders to a massive extent.
Solar installer costs are broadly comparable as Australians are better qualified and even if they weren't comparable the fraction of the cost isn't enough to explain the total difference.
There's various studies comparing the two countries, Tesla did one and found various technical approach changes and permitting reforms. It suggests labor is 7% of the cost in the US. Soft costs around acquisition, sales and marketing can be 18%.
What kind of power we're talking about here? I was quoted €10600 (around half of which will be government-subsidized) for 8 kWp worth of panels + 10.24 kWh battery storage, including project documentation (for subsidies), labor, and materials.
50k?
I could fly there, stay somewhere nice, buy a decent truck, put the solar PV on your roof, and make it home with 20k in my pocket to upgrade my solar power with and a truck.
The installation is straightforward, but the problem comes when you want to connect to the grid, because you have to get it approved by the utility. I'm sure getting a DYI installation approved by the utility is _possible_, but I wouldn't count on it. And, you may not know that you got disapproved until you've made the investment and are sort of screwed.
What I did was install solar with batteries and inverters that have the ability to never export power to the utility. That way I didn't have to tell them or seek their approval.
I picked a random spot in New York state. It looks like the solar generation in January is about 68% of July. As solar keeps getting cheaper, one option is to just install more solar.
Don't get me wrong, there are still issues here, like snow or back-to-back-to-back cloudy days. But the rate of a price change for solar has been pretty dramatic.
I installed a modest solar system (5kwh) in 2024 and was incredibly happy with the results. On any given 24 hour period it'd offset 40% of my electricity consumption (EV, hot tub being the big loads).
Last year I installed a cold climate heat pump. I'm incredibly happy with the switch from gas as my primary heat source. The solar now only covers ~15-20% of my consumption in winter.
So my solution this year will be to add more solar.
In the two years since I installed mine prices have halved. I'm fortunate enough to be able to do a DIY install, properly permitted and inspected, for about $350/400w panel once you factor in inverters, mounts, etc.
Coal-powered steam turbine is not that more efficient than a portable gas generator so considering coal is more carbon-intensive it's actually about the same or even worse in terms of emissions if you consider coal burning also produces mercury. Now nat gas-powered CCGT - different story. Good news is NYC is mostly powered by the latter and there's zero coal.
Weirdly (well not for me it's a charter metal festival cruise) I am too and interested in doing the same. Typically we use Uber and it's been a not great experience.
Having people making the same stupid comment after 3 decades needs to be handled more critically
Let’s go back 40 years and listen to the warning:
https://youtu.be/3NvgJ1b6JXs?si=yUKcegVwfyNGi2rC
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