I've been using it since it came out for Windows a week or two ago, and it's wonderfully fast (as well as beautiful). Using Opera used to feel like sacrificing performance for functionality, but now I feel like I have the best of both worlds. It is still beta, and there are a couple bugs, but for the most part it's a great experience.
Which Firefox extensions would you miss if you used Opera? Opera has built in support for tab thumbnails, mouse gestures, Greasemonkey scripts, widgets, etc.
Opera 10.50 has new search highlighting, though, and the right-click context menu for highlighted text has included a translate option for a while now.
Tree style tabs would be better if the tab panel would expand and put thumbnails under the links. I don't like that they automatically collapse either.
I tried it for OS X, but scrolling sucks and I can't seem to adjust it. There's also some other little things I keep finding that annoy me... It may be faster than Safari, but not compellingly so.
I installed it, it lost my saved tabs, and the sidebar looks out of place. I recovered my old version via Time Machine, so until they bring out a stable version, I will wait for thee.