Yes, for the two days of high dose IL-2 every 8 hours, it was pretty bad. My experience was limited to nausea, fever, sweating, and bed-shaking rigors. I've heard that some patients experience hallucinations.
Note: IL-2 was administered after I received my lab-grown white blood cells. It acts as signal to one's immune system to activate. It was used to jumpstart my immune system after it had been replaced.
I wonder how a combination of aggressive immunotherapy and "sickness" counteracting effects of cannabis (for the nausea, fever, sweating) would do in making the immunothrerapy more effective and tolerable.
Since the treatment was performed on site at the National Institutes of Health using Federal research dollars, this wouldn't have been an option. So, I have no idea.