CS50 should really stick with C and go as deep as possible. But it's good to learn multiple languages in the same course -- even then I prefer they put a functional language like Scala instead of Python. I mean once you know C it's really easy to pick up Python by yourself.

I'd say 50% C and 50% Functional, and remove the web part, really superficial and boring. And then go as deep as possible. Can even intertwine the C/Functional part, e.g. write an interpreter for a subset of the functional language in C as the last large project.

CS50 is good, but I personally don't like it. I prefer MIT/Princeton/UCB intro courses comparatively. CS50 starts off with C for 3-4 weeks IIRC. Then moves on to python/sql/webdev. Not only is this fast paced, but it also covers a lot of breadth in a short time. For a self learner who has a full time job without proper support structure like peers and office hours which you get in the on campus version, it is difficult (not impossible) to go with the pace of the course. I do agree Malan is a great instructor.

In contrast, I like the MIT/Princeton/UCB courses since they use an easier language to start with and also introduce C in the later courses for systems programming.

I found CS50’s schedule very difficult to keep up with while working full-time. I fell behind at points but I didn’t find much if any penalty in taking a little longer to finish the class. I was motivated and putting the time in to absorb the material to the point where I was satisfied.

edx still has last years version online (I think until like mid-January), so if anybody wants to start between now and then, use: https://cs50.harvard.edu/college/ for the latest Fall 2019 edition.

You can still switch to edx as soon as it's live there.