I used this to remove ads from Instagram. It's a wonderful tool that gives you godlike powers over other people's apps when you know what you're doing.
Yes. I injected my own code in there that intercepts HTTP responses and rewrites them as needed before giving them to the rest of the app. I was able to do this in a way that's portable across versions because they use an HTTP client written in C++, which needs JNI bindings, which can't be obfuscated.