Yes, I could imagine a very locked down opinionated distro built on top of Nix that completely abstracts away all of it and makes it work somewhat like Ubuntu with some prepared nix templates/metaprogramming to automatically generate config. Over time more of the Nix functionality could be exposed through UI or more friendly cli tools as best practices and nix itself evolve, allowing the distro to remain friendly to non-technical users while opening up it's true powers to them.
It wouldn't be able to handle arbitrary manual changes to config at the beginning, so either there would always be a protected generated config region of the whole config and the distro would remain relatively standardized, or an alternative evolution would be a low-code user friendly UI that could map to any possible nix config.
It wouldn't be able to handle arbitrary manual changes to config at the beginning, so either there would always be a protected generated config region of the whole config and the distro would remain relatively standardized, or an alternative evolution would be a low-code user friendly UI that could map to any possible nix config.