The early studies were with Paxlovid in unvaccinated patients, where it worked pretty good. But by now everyone is vaccinated and/or has caught the pestilence several times over, and efficacy against severe disease and death is much less clear-cut. It still provides benefit in the elderly, but not in the rest of the population.

Pfizer (!) put out a press release bearing the not-good news: https://www.pfizer.com/news/press-release/press-release-deta...