At the risk of sounding insensitive: an ounce of prevention is worth more than a pound of cure—this is one of those things that if it's a problem someone is experiencing, that thing is not their real problem, which is a deep failure somewhere else, way, way back.
The unvarnished truth is that the answer to your question ("how do you stop your wife and/or kids interrupting you every 30 seconds?") for many people is "I don't". They don't stop them, that is. Because they don't have to. Because they didn't marry someone who interrupts them every 30 seconds and then have kids with them and then raise those kids to be the kinds of kids who interrupts them every 30 seconds.
I tell both my kids "don't stay up too late" just before I go to bed (usually around 11pm). Beyond a certain age you can't force them anymore and they have to learn their limits themselves.
There are weekends where I spent 3 to 4 hours reading at the public library. It is definitely a deliberate act, not always supported by other family members but it is possible. I am able to do 20 to 30 books a year. All the best! I hope you are able to get started. Happy reading.
I also I have a huge backlog of tech books that I should work on because this career kinda requires it.