I've worked over the last two years on a library called Falcon.js (http://stoodder.github.io/falconjs/). It's your typically MVC/MVVM structure with similar concepts as Backbone (Models, Collections, Views). But utilizes the awesome data-binding architecture of Knockout. Falcon's core belief is that front-end developers shouldn't explicitly have javascript mixed with html (or vice versa). This is made possible only because of how Knockout handles data binding and templating. Falcon adds common sense architecture around that belief. Take a look! I'm always excited for feedback. I've use Falcon in many production level apps both for desktop web and mobile hybrid apps.