"But when somebody uses his mouse to click somewhere and expects something to change, things might get tough. If you're lucky, it's just a local action, like a dropdown menu that needs to open. If you're unlucky, it's some complex filter action on your data heavy app that causes three ajax requests and changes to seven models."

Reading this I start to think if isolated javascript components and a jquery pubsub system publishing the 'newclick' event from the server isn't simpler and more modular..