Most rural places have little in the way of zoning. As long as you aren't putting a nuclear waste plant (and maybe even then if it has good jobs) next door to a public grade school then you're normally fine.
Zoning issues are the biggest generally in big cities or areas of rapid expansion.
My family lives in the heart of amish country, and the local boards are a bunch of power tripping bureaucrats. They will ruthlessly shut down little old ladies who try to sell jelly.
Zoning is a huge issue, as it is a township's first line of defense against people who want to change things.
Zoning issues are the biggest generally in big cities or areas of rapid expansion.